Neuroblastoma

This book provides a state-of-the-art review of neuroblastoma, integrating the latest discoveries in tumor biology, genomics, immunology, and precision medicine. Organized around the concepts of the “seed” (tumor genomics, epigenetics, metabolism, stem cells) and the “soil” (tumor microenvironment, immunity, exosomes), it highlights how these factors inform current and emerging therapeutic strategies, including targeted molecular and immunotherapies. The text also addresses relapsed/refractory disease, methods for evaluating tumor burden, and advances in immune and cellular therapies.

Key Features:

• Offers an up-to-date synthesis of neuroblastoma biology and genetics.
• Explores the tumor microenvironment and immune mechanisms as therapeutic targets.
• Reviews precision medicine approaches, including molecular therapies and immunotherapies.
• Covers relapsed/refractory neuroblastoma and novel methods for tumor burden assessment.
• Bridges experimental research and clinical care for a broad readership of oncologists and researchers.