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This resource provides a comprehensive overview of gliomas, focusing on the molecular, metabolic, diagnostic, and surgical aspects of these brain tumors. It highlights the role of key genetic mutations such as TP53, IDH1, and IDH2 in gliomagenesis, explains the metabolic heterogeneity across tumor regions, and details both low- and high-grade gliomas. The book also covers advanced imaging techniques, including PET, SPECT, and intraoperative MRI, and explores how these guide diagnosis, treatment planning, and surgical management, particularly in high-grade tumors like glioblastoma multiforme.
Key Features
- Advantages and limitations of biomarkers in glioma diagnosis and prognosis.
- Detailed explanation of molecular subtypes and the role of TP53, IDH1, and IDH2 mutations.
- Insight into metabolic differences within tumor regions and their clinical implications.
- Overview of imaging modalities (PET, SPECT, MRI) for diagnosis and treatment guidance.
- Discussion of conventional and fluorescence-guided resection techniques for high-grade gliomas.
- Emphasis on the impact of resection extent on patient outcomes.
- Role of intraoperative low-field MRI in improving surgical accuracy and safety.
